Base 50

In base 50, each digit position represents a power of 50: the rightmost digit counts individual ones, the next counts groups of 50, the next counts groups of 50×50, and so on — the same place-value idea as base 10, just with 50 distinct digits instead of ten.

Base 21

Base 21 works the same way: the rightmost digit counts ones, the next counts groups of 21, the next counts groups of 21×21, and so on, using 21 distinct digits.